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In the Transwell invasion assay, a significant increase in the number of membrane-penetrating TPC-1 cells was observed in RRM2 overexpressing group as compared to the control group, and a significant increase in the number of membrane-penetrating cells in the IHH4 cell line, a trend consistent with TPC-1 cells was observed ( Figure 7C , Supplementary Figure S6 )
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Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells
